Thursday, December 31, 2009

PSA - Benefits of Vitamin C . . . (Part Three)


National Institute of Health Confirms Vitamin C Effectiveness

National Institute of Health / National Cancer Institute – “Early clinical [Cameron/Pauling] studies showed that high-dose - oral OR intravenous vitamin c, may improve symptoms and prolong life in patients with terminal cancer. Double-blind placebo-controlled [Mayo Clinic] studies of oral vitamin C therapy showed no benefit. Recent evidence shows that oral administration of the maximum tolerated dose of vitamin C (18 g/d) produces peak plasma concentrations of only 220 µmol/L, whereas intravenous administration of the same dose produces plasma concentrations about 25-fold higher. Larger doses (50–100 g) given intravenously may result in plasma concentrations of about 14 000 µmol/L. At concentrations above 1000 µmol/L, vitamin C is toxic to some cancer cells but not to normal cells in vitro.

We found 3 well-documented cases of advanced cancers, confirmed by histopathologic review, where patients had unexpectedly long survival times after receiving high-dose intravenous vitamin c iv therapy. We examined clinical details of each case in accordance with National Cancer Institute (NCI) Best Case Series guidelines. Tumour pathology was verified by pathologists at the NCI who were unaware of diagnosis or treatment. In light of recent clinical pharmacokinetic findings and in vitro evidence of anti-tumour mechanisms, these case reports indicate that the role of high-dose intravenous vitamin c iv therapy in cancer treatment should be reassessed.”

Dr. Mark Levine of the National Institutes of Health in Bethesda, Maryland, and colleagues note that, in vitro, vitamin C is toxic to some cancer cells but not normal cells at concentrations above 1000 µmol/L. IV doses in the range of 50-100 g result in plasma levels of about 14,000 µmol/L.

The team analyzed clinical and histological data from three patients with advanced cancer who responded to high-dose IV vitamin C.

The first patient was a 51 year-old-women with advanced renal cell carcinoma, treated with nephrectomy, and several small lesions in the lung "consistent with metastatic cancer." She received IV vitamin C 65 g twice a week for 10 months, in combination with other alternative therapies, including thymus protein extract. Repeat chest radiography revealed one small spot, assumed to be a scar. Five years later, new lung masses were detected.

The patient again received intravenous vitamin c, with unsuccessful results. The second patient, a 49-year-old man, had bladder cancer with multiple satellite tumors. He received IV vitamin C 30 g twice a week for three months, followed by 30 g vitamin C once every 1-2 months for four years. . Nine years after diagnosis, the patient is in good health, without signs of disease.

Case three was a 66-year-old woman with B-cell lymphoma invading paraspinal muscle and bone at L4-5. She received IV vitamin C 15 g twice weekly for 7 months, then 15 g every 2-3 months for about one year. Ten years after diagnosis, the patient is in good health.

Dr. Levine and colleagues note that all three patients survived for longer than expected for the types and stages of cancers that they had. At the doses delivered, vitamin C "is a pro-drug for hydrogen peroxide formation in extracellular fluid," they explain. Histology results also showed evidence of tumor hemorrhage, attributable to ascorbate.

The investigators conclude that "the role of high-dose intravenous vitamin c therapy in cancer treatment should be reassessed."

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